http://qjmed.oxfordjournals.org/content/105/12/1151
Dit vind ik bijv. ook zo'n interessante opmerking:
Vaccines, using whole killed leptospires, have been given to domestic and agricultural animals since the early 1900s.65 However, a safe vaccine for humans has yet to be found, as whole leptospire-based vaccines have unacceptably high levels of side effects in humans.66 Additionally, the protection provided was short lived and the immunity acquired is serovar-specific.67 The wide variety of pathogenic serovars and complex immunology involved in the response to these bacteria means vaccine design is an ongoing challenge. A more thorough discussion of this is outside the scope of this article, but has recently been extensively reviewed elsewhere.68