Cathy schreef:
Wat ik gelezen heb zijn dit de soorten die een hond kan krijgen , L. bratislava, L. canicola, L. grippotyphosa,
L. icterohaemorrhagiae, L. pomoma, L.saxkoebing en L. sejroe.
Mijn vraag , is elk soort met een bloedonderzoek aan te tonen in nl ? of kijken ze alleen naar de soorten die in een enting zitten ?
Serologic tests—
The microscopic agglutination test (MAT) is the most commonly used
technique for diagnosing leptospirosis in animals. Serology is inexpensive, reasonably sensitive, and
widely available. The MAT involves mixing appropriate dilutions of serum with live leptospires of
serovars prevalent within the region. The presence of antibodies is indicated by the agglutination of the
leptospires.
Detection of high titers of antibody in animals with a disease consistent with leptospirosis may be
sufficient to establish the diagnosis. This is particularly true in the investigation of abortions caused by
incidental host infections in which the dam’s agglutinating antibody titer is >
800-1600. However, in
maintenance host infections, particularly serovar Hardjo infection, infected animals often have a poor
antibody response to infection. Often at the time of abortion, antibody titers may be quite low or
negative against serovar Hardjo. In these cases, the herd serologic response to infection or detection of
the organism in tissues or fluids are often more helpful than is the individual’s antibody titer in
establishing the diagnosis.
Interpretation of leptospiral serologic results is complicated by a number of factors. These
factors include: cross-reactivity of antibodies, antibody titers induced by vaccination, and lack of
consensus about what antibody titers are indicative of active infection. Antibodies produced in an
animal in response to infection with a given serovar of
Leptospira
often cross-react with other serovars
of leptospires. Therefore, a cow infected with a single serovar is likely to have antibodies against more
than one serovar in an agglutination test. Patterns of cross-reactive antibodies vary widely between
species of animals and between individuals within a species. However, in general, the infecting serovar
is assumed to be the serovar to which that animal develops the highest titer.
Widespread vaccination of cattle with leptospiral vaccines also complicates the interpretation of
leptospiral serology. In general, vaccinated cattle develop relatively low agglutinating antibody titers
(100 to 400) to the serovars in the vaccine and these titers persist for one to three months after
vaccination. However, some animals develop high titers after vaccination (particularly those vaccinated
several times each year) and although these high vaccination titers decrease with time, they may persist
for six months or more after vaccination. Introduction of new vaccines may also change the typical
pattern of post-vaccination antibody titers.
The third complication of interpretation of leptospiral serological testing is caused by a lack of
consensus as to what titer is “significant” for the diagnosis of leptospiral infection.
Link:
http://www.wdmc.org/2003/Diagnosis%20an ... irosis.pdf
Wat ik hier uit begrijp is dat wel het serovar uit de titertest komt maar dat er een besmetting/ziekte kan zijn voor 1 bepaalde serovar en andere toch ook verhoogd kunnen zijn.